Location:Home >>Scientist >> Faculty
Contact Information
Name  
Feng GE
Academic Title  
  Professor
Education  
  Ph.D.
Phone  
  86-27-68780500
 E-mail 
  gefeng@ihb.ac.cn

Personal Profile:

Dr. Ge is a Professor of Institute of Hydrobiology, Chinese Academy of Sciences (CAS), China. He is the awardees of Hundred Talents Program of CAS and Leader of Functional Proteomics Group. He studied Biology at the Shandong University, and received his Master degree from Wuhan Institute of Virology, CAS and Ph.D. degree from National University of Singapore. His research has focused on the application of quantitative proteomics to biological problems, particularly in the area of protein-protein interactions and post-translational modifications (PTMs). Professor Ge’s laboratory develops and applies methods of mass spectrometry (MS)-based proteomics in a variety of biological areas. He has published over 40 papers in peer-review international journals and has lectured in many international meetings. He is a member of American Chemical Society and Associated Editor of Journal of Integrated OMICS. 


Research Directions:

1. Mass spectrometry (MS)-based proteomics   

We are using state-of-the-art mass spectrometric methods for identification of proteins and for characterizing post-translational modifications in signal transduction pathways and in the analysis human and several different organisms. We are using different techniques that help us quantitate levels of protein as well as post-translational modifications. We are also developing computational methods that allow us to extract annotated information from existing databases including genomic databases while performing searches using mass spectrometry-derived data. 

2. Functional Proteomic Analysis of miRNA and LincRNA Targets  

We have used a quantitative proteomic approach to identify targets of miR-21 at the protein level. miR-21 is a miRNA that has been reported to be associated with multiple cancer-related processes including proliferation, apoptosis, invasion, and metastasis. This study was published in the Journal of Proteome Research. Given the success of this approach, we are embarking on carrying out systematic proteomic analyses to identify targets of miRNAs and Large intervening non-coding RNA (LincRNA) that are involved in cancers.
Social Titles:

Awards & Honors:
Recent Publications:

1. Chen, Zhuo; Zhang, Guiying; Yang, Mingkun; Li, Tao*; Ge, Feng*; Zhao, Jindong. Lysine Acetylome Analysis Reveals Photosystem II Manganese-stabilizing Protein Acetylation is Involved in Negative Regulation of Oxygen Evolution in Model Cyanobacterium Synechococcus sp. PCC 7002. Molecular & Cellular Proteomics. 2017;16(7):1297-1311. *Corresponding Author 

2. Ma, Yanyan; Yang, Mingkun; Lin, Xiaohuang; Liu, Xin; Huang, Hui; Feng Ge*. Malonylome Analysis Reveals the Involvement of Lysine Malonylation in Metabolism and Photosynthesis in Cyanobacteria. Journal of Proteome Research. 2017;16(5):2030-2043. *Corresponding Author 

3. Jia Zhang, Ming-kun Yang, Honghui Zeng, and Feng Ge*. GAPP: A Proteogenomic Software for Genome Annotation and Global Profiling of Post-translational Modifications in Prokaryotes. Molecular & Cellular Proteomics. 2016;15(11):3529-3539. *Corresponding Author 

4. 吴英; 熊倩; 葛峰*. 长链非编码RNA HOTAIR在细胞增殖中的作用机制. 生命科学. 2016, 28: 6; 680-685. *Corresponding Author 

5: Wu Y, Lou QY, Ge F, Xiong Q.*. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Scientific Reports. 2017; 7(1):4022. *Corresponding Author 

6: Ren S, Yang M, Li Y, Zhang F, Chen Z, Zhang J, Yang G, Yue Y, Li S, Ge F*, Wang S.*. Global Phosphoproteomic Analysis Reveals the Involvement of Phosphorylation in Aflatoxins Biosynthesis in the Pathogenic Fungus Aspergillus flavus. Scientific Reports. 2016; 6: 34078. *Corresponding Author 

7. Siting Li, Minghai Chen, Qian Xiong, Jia Zhang, Zongqiang Cui, Feng Ge*. Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer Cells. Journal of Proteome Research. 2016, 7;15(10):3741-3751. *Corresponding Author 

8. 杨明坤;林小煌;马炎炎;王炎;葛峰*. 蓝藻的蛋白质翻译后修饰研究进展. 水生生物学报,2016 (05)1056-1067. *Corresponding Author 

9: Ming-kun Yang, Yao-hua Yang, Zhuo Chen, Jia Zhang, Yan Lin, Yan Wang, Qian Xiong, Tao Li*, Feng Ge*, Donald A. Bryant, and Jin-dong Zhao. Proteogenomic analysis and global discovery of post-translational modifications in prokaryotes. Proceedings of the National Academy of Sciences of the United States of America201411152):E5633-E5642*Corresponding Author 

10: Peng ZhengQian XiongYing WuYing ChenZhuo ChenJoy FlemingDing GaoLijun BiFeng Ge*Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Non-coding RNA HOTAIR in HeLa CellsMolecular & Cellular Proteomics, 2015, 14 (5) :1447-63. *Corresponding Author 

11: Feng Ge, Weichao Huang, Zhuo Chen, Chunye Zhang, Qian Xiong, Chris Bowler, Juan Yang, Jin Xu, and Hanhua Hu. Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum Plant Cell 2014; 26(4):1681-1697. *Corresponding Author 

12: Ziyad Tariq Muhseen, Qian Xiong, Zhuo Chen and Feng Ge*. Proteomics studies on stress responses in diatoms. Proteomics. 2015; 15(23-24):3943-53. *Corresponding Author 

13: Zhuo Chen, Jiao Zhan, Ying Chen, Mingkun Yang, Chenliu He, Feng Ge*, Qiang Wang*. Effects of Phosphorylation of β Subunits of Phycocyanins on State Transition in the Model Cyanobacterium Synechocystis sp. PCC 6803. Plant and Cell Physiology. 2015, 56 (10): 1997-2013. *Corresponding Author 

14: Qian Xiong, Zhuo Chen, Feng Ge*. Proteomic analysis of post translational modifications in cyanobacteria. Journal of Proteomics. 2016; 134:57-64. *Corresponding Author 

15: Mingkun Yang, Yan Wang, Ying Chen, Zhongyi Cheng, Jing Gu, Jiaoyu Deng, Lijun Bi, Chuangbin Chen, Ran Mo, Xude Wang, and Feng Ge*. Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis H37Rv. Molecular & Cellular Proteomics201514 (4): 796-811*Corresponding Author 

16: Qian XiongJie FengSi-ting LiGui-ying ZhangZhi-xian QiaoZhuo ChenYing WuHui HuangYan LinTao Li*Feng Ge*Jin-dong Zhao*. Integrated Transcriptomic and Proteomic Analysis of the Global Response of Synechococcus sp. PCC 7002 to High Light Stress. Molecular & Cellular Proteomics2015; 14(4): 1038-53*Corresponding Author 

17: Yang, YaohuaFeng, JieLi, Tao*Feng Ge*Zhao, Jindong. CyanOmics: an integrated database of omics for the model cyanobacterium Synechococcus sp. PCC 7002. Database (Oxford)2015 Jan 28;2015. pii: bau127. doi: 10.1093/database/bau127. *Corresponding Author 

18: Ran Mo, Mingkun Yang, Zhuo Chen, Zhongyi Cheng, Xingling Yi, Chongyang Li, Chenliu He, Qian Xiong, Hui Chen, Qiang Wang*, and Feng Ge*. Acetylome Analysis Reveals the Involvement of Lysine Acetylation in Photosynthesis and Carbon Metabolism in the Model Cyanobacterium Synechocystis sp. PCC 6803. Journal of Proteome Research 2015142: 1275-1286*Corresponding Author 

19: Fengying Liu, Mingkun Yang, Xude Wang, Shanshan Yang, Jing Gu, Jie Zhou, Xian-En Zhang*, Jiaoyu Deng*, and Feng Ge*. Acetylome analysis reveals diverse functions of lysine acetylation in Mycobacterium tuberculosis. Molecular & Cellular Proteomics 2014; 13(12):3352-66 *Corresponding Author 

20: Zhuo Chen, Ming-kun Yang, Chong-yang Li, Yan Wang, Jia Zhang, Dian-bing Wang, Xian-en Zhang*, and Feng Ge*. Phosphoproteomic Analysis Provides Novel Insights into Stress Responses in Phaeodactylum tricornutum, a Model Diatom. Journal of Proteome Research 2014; 13(5): 2511-23 *Corresponding Author 

21: Miao Tian, Xiulan Chen, Qian Xiong, Jie Xiong, Chuanle Xiao, Feng Ge*, Fuquan Yang*, and Wei Miao*. Phosphoproteomic analysis of protein phosphorylation networks in Tetrahymena thermophila, a Model Single-Celled Organism. Molecular & Cellular Proteomics 2014;13(2):503-19. *Corresponding Author 

22: Ying Chen, Li-Na Yang, Li Cheng, Shun Tu, Shu-Juan Guo, Huang-Ying Le, Qian Xiong, Ran Mo, Chong-Yang Li, Jun-Seop Jeong, Lizhi Jiang, Seth Blackshaw, Li-Jun Bi, Heng Zhu*, Sheng-Ce Tao*, and Feng Ge*. BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Molecular & Cellular Proteomics 2013;12(10):2804-19. *Corresponding Author 

23: Ming-kun Yang, Zhi-xian Qiao, Wan-yi Zhang, Qian Xiong, Jia Zhang, Tao Li*, Feng Ge*, and Jin-dong Zhao*. Global phosphoproteomic analysis reveals diverse functions of Serine/Threonine/Tyrosine phosphorylation in the model cyanobacterium synechococcus sp. strain PCC 7002. Journal of Proteome Research 2013, 12 (4), 1909–1923. *Corresponding Author 

24: Chongyang Li, Qian Xiong, Jia Zhang, Feng Ge* and Li-Jun Bi. Quantitative Proteomic Strategies for the Identification of MicroRNA Targets. Expert Review of Proteomics 2012;9(5):549-59 *Corresponding Author 

25: Qian Xiong, Qiu Zhong, Jia Zhang, Mingkun Yang, Chongyang Li, Peng Zheng, Li-Jun Bi*, and Feng Ge*. Identification of Novel miR-21 Target Proteins in Multiple Myeloma Cells by Quantitative Proteomics. Journal of Proteome Research 2012; 11(4):2078-90 *Corresponding Author 

26: Peng Zheng, Qiu Zhong, Qian Xiong, Mingkun Yang, Jia Zhang, Chongyang Li, Li-Jun Bi*, Feng Ge*. QUICK identification and SPR validation of signal transducers and activators of transcription 3 (Stat3) interacting proteins. Journal of Proteomics 2012; 75(3):1055-66. *Corresponding Author 

27: Jia Zhang, Fangjin Chen, Wenliang Li, Qian Xiong, Mingkun Yang, Peng Zheng, Chongyang Li, Jianfeng Pei*, Feng Ge*. 14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells. PLoS One 2012;7(1):e29554. *Corresponding Author 

28: Qian Xiong, Feng Ge*. Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients. Expert Review of Proteomics 2011;8(4):439-42 *Corresponding Author 

29: Feng Ge*, Li-Jun Bi, Sheng-Ce Tao, Xudong Xu, Zhi-Ping Zhang, Kaio Kitazato and Xian-En Zhang*. Proteomic analysis of multiple myeloma: current status and future perspectives. Proteomics Clin Appl 2011; 5:30-37. *Corresponding Author 

30: Feng Ge*, Shengce Tao, Lijun Bi, Zhiping Zhang, and Xianen Zhang*. Proteomics: addressing the challenges of multiple myeloma. Acta Biochim Biophys Sin (Shanghai) 2011; 43:89-95. *Corresponding Author 

31: Feng Ge*, Liang Zhang, Sheng-Ce Tao, Kaio Kitazato, Zhi-Ping Zhang, Xian-En Zhang, and Li-Jun Bi*. Quantitative proteomic analysis of tumor reversion in multiple myeloma cells. Journal of Proteome Research 2011;10(2):845-55. *Corresponding Author 

32: Feng Ge*, Wen-Liang Li, Li-Jun Bi, Sheng-Ce Tao, Zhi-Ping Zhang, and Xian-En Zhang. Identification of novel 14-3-3ζ interacting proteins by quantitative immunoprecipitation combined with knockdown (QUICK). Journal of Proteome Research 2010 Nov 5;9(11):5848-58. *Corresponding Author 

  


Grants & Research Projects: