Education: 

Ph.D., Hydrobiology, Institute of Hydrobiology, Chinese Academy of Sciences, 2005 

M.S., Aquaculture, Huazhong Agricultural University, 2001 

Research Experience: 

Professor (01/2015-present): Hydrobiology, Institute of Hydrobiology, Chinese Academy of Sciences 

Visiting Scholar (04/2009-04/2010): Scottish Fish Immunology Research Centre; School of Biological Sciences, University of Aberdeen, Aberdeen, UK 

Honorary Research Fellow (06/2008-11/2008): Scottish Fish Immunology Research Centre; School of Biological Sciences, University of Aberdeen, Aberdeen, UK 

Associate Professor (08/2007-12/2014): Hydrobiology, Institute of Hydrobiology, Chinese Academy of Sciences 

Research Assistant (02/2005-07/2007): Hydrobiology, Institute of Hydrobiology, Chinese Academy of Sciences 

1.  Fish immunology 
2.  The interaction between fish and pathogen  
3.  Signaling mechanisms regulating innate immune responses in teleost fish 

　　1. Chang MX, Zou J, Nie P, Huang B, Yu Z, Collet B, Secombes CJ*. Intracellular interferons in fish: A unique means to combat viral infection. PLOS Pathogens. 2013, 9(11):e1003736. 

　　2. Chang M, Collet B, Nie P*, Lester K, Campbell S, Secombes CJ, Zou J*. Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in rainbow trout (Oncorhynchus mykiss). J Virol. 2011,85(16):8403-12.  

　　3. Chang MX, Wang T, Nie P, Zou J, Secombes CJ*. Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish Shellfish Immunol. 2011,30(1):118-27.  

　　4. Chang MX, Chen WQ, Nie P*. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Dev Comp Immunol. 2010;34:1-13.  

　　5. Chang MX, Wang YP, Nie P*. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish Shellfish Immunol. 2009;26:264-74.  

　　6. Chang MX, Nie P, Collet B, Secombes CJ, Zou J*. Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics 2009;61:315-25. 

　　7. Chang MX, Nie P*. RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Vet Immunol Immunopathol. 2008;124:295-301. 

　　8. Chang MX, Nie P*, Wei LL. Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Mol Immunol. 2007;44(11):3005-23.  

　　9. Chang MX, Sun BJ, Nie P*. The first non-mammalian CXCR3 in a teleost fish: gene and expression in blood cells and central nervous system in the grass carp (Ctenopharyngodon idella). Mol Immunol. 2007;44(6):1123-34.  

　　10. Fan Y, Chang MX, Ma J, LaPatra SE, Hu YW, Huang L, Nie P*, Zeng L*. Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus. Vet Res. 2015;46:136. 

　　11. Zhang L, Chen WQ, Hu YW, Wu XM, Nie P, Chang MX*. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish Shellfish Immunol. 2016;54:135-43. 

　　12. Zou PF, Chang MX*, Li Y, Zhang SH, Fu JP, Chen SN, Nie P*. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43(1):13-24.  

　　13. Zou PF, Chang MX*, Xue NN, Liu XQ, Li JH, Fu JP, Chen SN, Nie P*. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014;141(2):192-202.  

　　14. Li JH, Chang MX*, Xue NN, Nie P*. Functional characterization of a short peptidoglycan recognition protein, PGRP5 in grass carp Ctenopharyngodon idella. Fish Shellfish Immunol. 2013;35(2):221-30.  

　　15. Chen WQ, Hu YW, Zou PF, Ren SS, Nie P, Chang MX*. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49(1):19-30. 

　　16. Yu ZL, Li JH, Xue NN, Nie P, Chang MX*. Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;47(2):264-74. 

　　17. Hu YW, Yu ZL, Xue NN, Nie P, Chang MX*. Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Dev Comp Immunol. 2014;46(2):323-32.  

　　18. Li JH, Yu ZL, Xue NN, Zou PF, Hu JY, Nie P, Chang MX*. Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;42(2):244-55.  

　　19. Wang G, Li J, Zou P, Xie H, Huang B, Nie P, Chang M*. Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2012;33(3):522-31.  

　　20. Guo HZ, Zou PF, Fu JP, Guo Z, Zhu BK, Nie P, Chang MX*. Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis. Fish Shellfish Immunol. 2011,30(2):515-24.