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Contact Information
Name  
 Yonghua SUN
Academic Title  
   Professor
Education  
   Ph.D.
Phone  
   86-27-68780235
 E-mail 
   yhsun@ihb.ac.cn

Personal Profile：

Education:

09/2006-03/2008:  FFCSA (La Fondation franco-chinoise pour la science et ses applications) post-doctoral research associate, IGBMC, France (Mentor: Profs. Bernard Thisse and Christine Thisse)

02/2005-08/2006:  Post-doctoral research associate, IGBMC, France (Mentor: Profs. Bernard Thisse and Christine Thisse)

09/1997-10/2002:  Ph.D. study at Institute of Hydrobiology, Chinese Academy of Sciences, China (Mentor: Prof. Zuoyan Zhu)

09/1993-07/1997:  BSc study at the College of Life Science, Wuhan University, China

Research Experience:

12/2010-present:  Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China

11/2011-present:  Director, National Zebrafish Resource Center, Institute of Hydrobiology, Chinese Academy of Sciences, China

01/2005-11/2010:  Associate Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China

11/2009-12/2009:  Visiting Associate Professor, Department of Cell Biology, University of Virginia, US

07/2002-12/2004:  Assistant Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China

 

Research Directions：

1) Early patterning and nuclear reprogramming of differentiated nucleus by using zebrafish as an animal model.

2) High-efficient gene targeting platform in fish system.

3) Directional genetic improvement of commercially important fishes based on gene manipulation, PGC manipulation and genome editing methods.

4) Collection, maintenance and utilization of zebrafish resources.

 

 
Social Titles：

Awards & Honors：

2011:  Member, Youth Innovation Promotion Association, Chinese Academy of Sciences (CAS)

2010:  Lu Jiaxi Young Talent Prize of the Chinese Academy of Sciences

2010:  Research Excellence Award, Institute of Hydrobiology, CAS

2010:  Travel Grant Award of the Fifth International Congress of the GRS and the IGF Society, New York

2009:  Research Excellence Award, Institute of Hydrobiology, CAS

2008:  Research Excellence Award, Institute of Hydrobiology, CAS

2006:  FFCSA (La Fondation franco-chinoise pour la science et ses applications) Fellowship Award

2005:  Research Excellence Award, Institute of Hydrobiology, CAS

2004:  Travel Award of the Sixth International Meeting on Zebrafish Genetics and Development, Madison, WI, US

2003:  Excellent Doctorate Dissertation Award of Hubei Province, China

2001:  Top Class Peng Yingang Award of Chinese Academy of Sciences, Beijing, China

 
Recent Publications：

　　1) Liu, L., Pan, L., Li, K., Zhang, Y., Zhu, Z. and Sun, Y.H.* (2016). Zebrafish Health Conditions in the China Zebrafish Resource Center and 20 Major Chinese Zebrafish Laboratories. Zebrafish 13 Suppl 1, S8-S18. 

　　2) He, M.-D., Zhang, F.-H., Wang, H.-L., Wang, H.-P., Zhu, Z.-Y. and Sun, Y.-H.* (2015). Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 780, 86-96. 

　　3) Pang, S.-C., Wang, H.-P., Zhu, Z.-Y. and Sun, Y.-H*. (2015). Transcriptional Activity and DNA Methylation Dynamics of the Gal4/UAS System in Zebrafish. Marine Biotechnology, 17(5):593-603. 

　　4) Xie, X., Pan, L. and Sun, Y.* (2015). Growing with the world: rapid development of the zebrafish research in China and the China Zebrafish Resource Center. Sci China Life Sci 58, 396-399. 

　　5) Ye, D., Zhu, Z. and Sun, Y.* (2015). Fish genome manipulation and directional breeding. Sci China Life Sci 58, 170-177. 

　　6) Wei Z-Q, Xiong F, He M-D, Wang H-P, Zhu Z-Y, Sun Y-H*. (2015) Suppression of Ligase 4 or Xrcc6 activities enhances the DNA homologous recombination efficiency in zebrafish primordial germ cells. Acta Hydrobiol. 39(2):339-48. 

　　7) Wei, C. Y., Wang, H. P., Zhu, Z. Y. and Sun, Y. H.* (2014). Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5. The Journal of Biological Chemistry 289, 6604-6618. 

　　8) Sun, Y. H.* and Zhu, Z. Y. (2014). Cross-species cloning: influence of cytoplasmic factors on development. J Physiol 592, 2375-2379. 

　　9) Lu, F.-I., Sun, Y.-H.*, Wei, C.-Y., Thisse, C. and Thisse, B. (2014). Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nat Commun 5, 5368. (*co-first author) 

　　10) Pang, S. C., Wang, H. P., Li, K. Y., Zhu, Z. Y., Kang, J. X. and Sun, Y. H.* (2014). Double Transgenesis of Humanized fat1 and fat2 Genes Promotes Omega-3 Polyunsaturated Fatty Acids Synthesis in a Zebrafish Model. Mar Biotechnol (NY) 16, 580-593. 

　　11) Xiong, F., Wei, Z. Q., Zhu, Z. Y. and Sun, Y. H.* (2013). Targeted Expression in Zebrafish Primordial Germ Cells by Cre/loxP and Gal4/UAS Systems. Mar Biotechnol (NY) 15, 526-539. 

　　12) Liu, C.-W., Xiong, F., Jia, H.-Z., Wang, X.-L., Cheng, H., Sun, Y.-H.*, Zhang, X.-Z., Zhuo, R.-X. and Feng, J. (2013a). Graphene-Based Anticancer Nanosystem and Its Biosafety Evaluation Using a Zebrafish Model. Biomacromolecules 14, 358-366. 

　　13) Wang, Y.-W., Wei, C.-Y., Dai, H.-P., Zhu, Z.-Y. and Sun, Y.-H.* (2013). Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation. Gene 521, 69-77. 

　　14) Ishtiaq Ahmed, A. S., Xiong, F., Pang, S. C., He, M. D., Waters, M. J., Zhu, Z. Y. and Sun, Y. H.* (2011). Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct. Transgenic Res 20, 557-567.  

　　15) Chen, C.-H., Sun, Y.-H.*, Pei, D.-S. and Zhu, Z.-Y. (2009). Comparative Expression of Zebrafish Lats1 and Lats2 and Their Implication in Gastrulation Movements. Developmental Dynamics 238, 2850-2859. 

　　16) Liu, Y., Bourgeois, C. F., Pang, S., Kudla, M., Dreumont, N., Kister, L., Sun, Y.-H., Stevenin, J. and Elliott, D. J. (2009). The Germ Cell Nuclear Proteins hnRNP G-T and RBMY Activate a Testis-Specific Exon. PLoS Genetics 5 (11): e1000707. 

　　17)Liu, J., Sun, Y. H.*, Wang, Y. W., Wang, N., Pei, D. S., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2008). Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology 70, 1525-1535. 

　　18) Pei, D. S., Sun, Y. H.*, Chen, C. H., Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2008). Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Dev Biol 8, 29. 

　　19) Pei, D. S., Sun, Y. H.*, Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2007). Identification of differentially expressed genes from the cross-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology 68, 1282-1291. 

　　20)Pei, D. S., Sun, Y. H.*, Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2007). Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Anal Biochem 363, 291-293. 

　　21)Wang, N., Sun, Y. H.*, Liu, J., Wang, Y. P. and Zhu, Z. Y. (2007). Molecular characterization of common carp (Cyprinus carpio) Sonic Hedgehog and discovery of its maternal expression. Development Genes and Evolution 217, 299-305. 

　　22)Wang, N., Sun, Y. H.*, Liu, J., Wu, G., Su, J. G., Wang, Y. P. and Zhu, Z. Y. (2007). Knock down of gfp and no tail expression in zebrafish embryo by in vivo-transcribed short hairpin RNA with T7 plasmid system. Journal of Biomedical Science 14, 767-776. 

　　23)Liu, J., Sun, Y. H.*, Wang, N., Wang, Y. P. and Zhu, Z. Y. (2006). Upstream regulatory region of zebrafish lunatic fringe: Isolation and promoter analysis. Marine Biotechnology 8, 357-365. 

　　24)Sun, Y. H., Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2005). Cytoplasmic impact on cross-genus cloned fish derived from transgenic common carp (Cyprinus carpio) nuclei and goldfish (Carassius auratus) enucleated eggs. Biol Reprod 72, 510-515. 

　　25)Liu, W. Y., Wang, Y., Sun, Y. H.*, Wang, Y. P., Chen, S. P. and Zhu, Z. Y. (2005). Efficient RNA interference in zebrafish embryos using siRNA synthesized with SP6 RNA polymerase. Development Growth & Differentiation 47, 323-331. 

　　26)Wu, B., Sun, Y. H.*, Wang, Y. W., Wang, Y. P. and Zhu, Z. Y. (2005). Characterization of transgene integration pattern in F4 hGH-transgenic common carp (Cyprinus carpio L.). Cell Research 15, 447-454. (* co-first author) 

　　27) Wu, B., Sun, Y. H.*, Wang, Y. P., Wang, Y. W. and Zhu, Z. Y. (2004). Sequences of transgene insertion sites in transgenic F4 common carp. Transgenic Research 13, 95-96. (* co-first author) 

　　28)Wu, G., Sun, Y. H.* and Zhu, Z. Y. (2003). Growth hormone gene transfer in common carp. Aquatic Living Resources 16, 416-420. (* co-first author) 

　　29)Sun, Y., Chen, S., Wang, Y. and Zhu, Z. (2000). The onset of foreign gene transcription in nuclear-transferred embryos of fish. Sci China C Life Sci 43, 597-605. 

　　30) Zhu, Z. Y. and Sun, Y. H. (2000). Embryonic and genetic manipulation in fish. Cell Research 10, 17-27. 

　　31) 张峰华, 王厚鹏, 黄思雨, 熊凤, 朱作言,孙永华* (2016). 两种密码子优化的 Cas9 编码基因在斑马鱼胚胎中基因敲除效率的比较. 遗传 38, 144-154. 

Grants & Research Projects：