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Lirong SONG
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B.S.,  Department of Biology, Nanjing University


Ph.D., Institute of Hydrobiology, the Chinese Academy of Sciences 

Research Experience:

Dr. Song is interested in the study of toxic cyanobacteria and its harmful metabolites such as toxin and off-flavor substances. Realizing that the colonial Microcystis are often the dominant form of the species in the field, he compared the difference in tolerance of colonial and single cell Microcystis and illustrated the phenomena why the colonial form dominate in the fields. He is also interested in the exploration of the mechanism of production and environmental fate of microcystins. Recently, he focuses on the dynamics of cyanobacterial bloom in several large shallow lakes, trying to find, in a long endeavor, the driving force govering the succession of algal species in the changing aquatic environments. 

Research Directions:

Ecology of toxic cyanobacteria and other bloom-forming algae

Aquatic eco-toxicology

Algal resources 
Social Titles:

Awards & Honors:
National award of excellence in field study (2009) 
Recent Publications:

  Zhou, Q.C., Chen, W., Shan, K., Zheng, L.L., Song, L.R., (2014). Influence of sunlight on the proliferation of cyanobacterial blooms and its potential applications in Lake Taihu, China. Journal of Environmental Sciences-China 26, 626-635.     

  Zhu, L., Wu, Y.L., Song, L.R., Gan, N.Q., (2014). Ecological Dynamics of Toxic Microcystis spp. and Microcystin-Degrading Bacteria in Dianchi Lake, China. Applied and Environmental Microbiology 80, 1874-1881.     

  Wu, Y.L., Li, L., Gan, N.Q., Zheng, L.L., Ma, H.Y., Shan, K., Liu, J., Xiao, B.D., Song, L.R., (2014). Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large, shallow, eutrophic Dianchi Lake. Journal of Environmental Sciences-China 26, 1921-1929. 

  Shan, K.LI, L.WANG, X.X.WU, Y.L.HU, L.L.YU, G.L., SONG, L.R., (2014). Modelling ecosystem structure and trophic interactions in typical cyanobacterial bloom-dominated shallow Lake Dianchi, China. Ecological Modelling 291: 82-95. 

  Ding, Yi, Song, Lirong, & Sedmak, Bojan. (2013). UVB radiation as a potential selective factor favoring microcystin producing bloom forming Cyanobacteria. PLoS One, 8(9), e73919.      

  Liu, Aiqiu, Zhu, Tao, Lu, Xuefeng, & Song, Lirong. (2013). Hydrocarbon profiles and phylogenetic analyses of diversified cyanobacterial species. Appl. Energy, 111, 383-393.      

  Yang, Chen, Zhang, Wei, Ren, Minglei, Song, Lirong, Li, Tao, & Zhao, Jindong. (2013). Whole-Genome Sequence of Microcystis aeruginosa TAIHU98, a Nontoxic Bloom-Forming Strain Isolated from Taihu Lake, China. Genome Announc, 1(3).      

  Yang, Wanwan, Tang, Zepei, Zhou, Fanqi, Zhang, Weihao, & Song, Lirong. (2013). Toxicity studies of tetracycline on Microcystis aeruginosa and Selenastrum capricornutum. Environ. Toxicol. Pharmacol., 35(2), 320-324.      

  Zhou, Qichao, Wei, Nian, Zheng, Lingling, & Song, Lirong. (2013). Host re-identification of cyanophage PP and its implications for host range and specificity. Virol Sin, 28(5), 306-308.      

  Chen, W., Jia, Y., Li, E., Zhao, S., Zhou, Q., Liu, L., and Song, L. (2012) Soil-Based Treatments of Mechanically Collected Cyanobacterial Blooms from Lake Taihu: Efficiencies and Potential Risks. Environ. Sci. Technol. 46, 13370-13376     

  Dai, G., Quan, C., Zhang, X., Liu, J., Song, L., and Gan, N. (2012) Fast removal of cyanobacterial toxin microcystin-LR by a low-cytotoxic microgel-Fe(III) complex. Water Res. 46, 1482-1489     

  Ding, Y., Gan, N., Li, J., Sedmak, B., and Song, L. (2012) Hydrogen peroxide induces apoptotic-like cell death in Microcystis aeruginosa (Chroococcales, Cyanobacteria) in a dose-dependent manner. Phycologia 51, 567-575     

  Dong, G., Xie, S., Zhu, X., Han, D., Yang, Y., Song, L., Gan, L., and Chen, W. (2012) Responses of yellow catfish (Pelteobagrus fulvidraco Richardson) exposed to dietary cyanobacteria and subsequent recovery. Toxicon 60, 1298-1306     

  Gan, N., Xiao, Y., Zhu, L., Wu, Z., Liu, J., Hu, C., and Song, L. (2012) The role of microcystins in maintaining colonies of bloom-forming Microcystis spp. Environ. Microbiol. 14, 730-742     

  Tan, X., Ma, P., Song, L., and Zhang, Q. (2012) Physiological and ultrastructural responses of Microcystis aeruginosa to different phosphorus concentrations. Fresenius Environ. Bull. 21, 838-843     

  Wang, Z., Xiao, B., Song, L., Wang, C., and Zhang, J. (2012) Responses and toxin bioaccumulation in duckweed (Lemna minor) under microcystin-LR, linear alkybenzene sulfonate and their joint stress. J. Hazard. Mater. 229-230, 137-144     

  Wu, X., Zheng, L., and Song, L. (2012) Development on a cryopreservation protocol of Microcystis aeruginosa using penetrating and non-penetrating cryoprotectants. Shuisheng Shengwu Xuebao 36, 344-351     

  Wu, Z., Zeng, B., Li, R., and Song, L. (2012) Combined effects of carbon and phosphorus levels on the invasive cyanobacterium, Cylindrospermopsis raciborskii. Phycologia 51, 144-150     

  Wu, Z., Zeng, B., Li, R., and Song, L. (2012) Physiological regulation of Cylindrospermopsis raciborskii (Nostocales, Cyanobacteria) in response to inorganic phosphorus limitation. Harmful Algae 15, 53-58     

  Zhang, J., Wang, Z., Song, Z., Xie, Z., Li, L., and Song, L. (2012) Bioaccumulation of microcystins in two freshwater gastropods from a cyanobacteria-bloom plateau lake, Lake Dianchi. Environ. Pollut. (Oxford, U. K.) 164, 227-234     

  Zhang, X., Song, L., Zhang, P., He, J., Liu, Y., Matsuura, H., and Watanabe, M. M. (2012) Grazing on toxic cyanobacterial blooms by tadpoles of edible frog Rana grylio. Phycol. Res. 60, 20-26     

  Zhou, Q., Chen, W., Zhang, H., Peng, L., Liu, L., Han, Z., Wan, N., Li, L., and Song, L. (2012) A flow cytometer based protocol for quantitative analysis of bloom-forming cyanobacteria (Microcystis) in lake sediments. J. Environ. Sci. (Beijing, China) 24, 1709-1716 

  Zhu, C., Chen, C., Zhao, L., Zhang, Y., Yang, J., Song, L., and Yang, S. (2012) Bioflocculant produced by Chlamydomonas reinhardtii. J. Appl. Phycol. 24, 1245-1251 

  Dong, G., Zhu, X., Han, D., Yang, Y., Song, L., and Xie, S. (2011) Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria. Environ Toxicol 26, 161-170     

  Jia, X., Shi, D., Shi, M., Li, R., Song, L., Fang, H., Yu, G., Li, X., and Du, G. (2011) Formation of cyanobacterial blooms in Lake Chaohu and the photosynthesis of dominant species hypothesis. Shengtai Xuebao 31, 2968-2977     

  Liu, L., Li, L., Zuo, Y., Huang, Y., and Song, L. (2011) Adsorption of 2-methylisoborneol and geosmin by a low-cost hybrid adsorbent synthesized from fly ash and bentonite. J. Water Supply: Res. Technol.--AQUA 60, 478-485     

  Peng, L., Chen, W., and Song, L. (2011) Study on extraction methods of intracellular microcystins. Shuisheng Shengwu Xuebao 35, 708-712     

  Sun, X., Mi, L., Liu, J., Song, L., Chung, F.-L., and Gan, N. (2011) Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice. Toxicol. Appl. Pharmacol. 255, 9-17     

  Wang, Z., Xiao, B., Song, L., Wu, X., Zhang, J., and Wang, C. (2011) Effects of microcystin-LR, linear alkylbenzene sulfonate and their mixture on lettuce (Lactuca sativa L.) seeds and seedlings. Ecotoxicology 20, 803-814     

  Wu, X., Wu, Z., and Song, L. (2011) Phenotype and temperature affect the affinity for dissolved inorganic carbon in a cyanobacterium Microcystis. Hydrobiologia 675, 175-186     

  Gan, N., Huang, Q., Zheng, L., and Song, L. (2010) Quantitative assessment of toxic and nontoxic Microcystis colonies in natural environments using fluorescence in situ hybridization and flow cytometry. Sci China Life Sci 53, 973-980     

  Gan, N., Mi, L., Sun, X., Dai, G., Chung, F.-L., and Song, L. (2010) Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response. Toxicol. Appl. Pharmacol. 247, 129-137     

  Gan, N., Sun, X., and Song, L. (2010) Activation of Nrf2 by Microcystin-LR Provides Advantages for Liver Cancer Cell Growth. Chem. Res. Toxicol. 23, 1477-1484     

  Peng, L., Liu, Y., Chen, W., Liu, L., Kent, M., and Song, L. (2010) Health risks associated with consumption of microcystin-contaminated fish and shellfish in three Chinese lakes: Significance for freshwater aquacultures. Ecotoxicol. Environ. Saf. 73, 1804-1811   

  Wang, Z., Xiao, B., Wu, X., Tu, X., Wang, Y., Sun, X., and Song, L. (2010) Linear alkylbenzene sulfonate (LAS) in water of Lake Dianchi-spatial and seasonal variation, and kinetics of biodegradation. Environ. Monit. Assess. 171, 501-512     

  Zhang, T., Li, L., Zuo, Y., Zhou, Q., and Song, L. (2010) Biological origins and annual variations of earthy-musty off-flavours in the Xionghe Reservoir in China. J. Water Supply: Res. Technol.--AQUA 59, 243-254     

  Zuo, Y., Li, L., Zhang, T., Zheng, L., Dai, G., Liu, L., and Song, L. (2010) Contribution of Streptomyces in sediment to earthy odor in the overlying water in Xionghe Reservoir, China. Water Res. 44, 6085-6094     

  Chen, W., Peng, L., Wan, N., and Song, L. (2009) Mechanism study on the frequent variations of cell-bound microcystins in cyanobacterial blooms in Lake Taihu: Implications for water quality monitoring and assessments. Chemosphere 77, 1585-1593     

  Chen, W., Zhang, C., Song, L., Sommerfeld, M., and Hu, Q. (2009) A high throughput Nile red method for quantitative measurement of neutral lipids in microalgae. J. Microbiol. Methods 77, 41-47     

  Dong, G., Zhu, X., Han, D., Yang, Y., Song, L., and Xie, S. (2009) Effects of dietary cyanobacteria of two different sources on growth and recovery of hybrid tilapia (Oreochromis niloticus × O. aureus). Toxicon 54, 208-216     

  Gong, Y., Chou, H.-N., Tu, C.-d., Liu, X., Liu, J., and Song, L. (2009) Effects of arsenate on the growth and microcystin production of Microcystis aeruginosa isolated from Taiwan as influenced by extracellular phosphate. J. Appl. Phycol. 21, 225-231     

  Gong, Y., Song, L., Wu, X., Xiao, B., Fang, T., and Liu, J. (2009) Effects of arsenate on microcystin content and leakage of Microcystis strain PCC7806 under various phosphate regimes. Environ. Toxicol. 24, 87-94     

  Hu, C., Gan, N., Chen, Y., Bi, L., Zhang, X., and Song, L. (2009) Detection of microcystins in environmental samples using surface plasmon resonance biosensor. Talanta 80, 407-410     

  Song, L., and Chen, W. (2009) Production of microcystins in bloom-forming cyanobacteria and their environmental fates: a review. Hupo Kexue 21, 749-757     

  Zhang, T., Li, L., Song, L., and Chen, W. (2009) Effects of temperature and light on the growth and geosmin production of Lyngbya kuetzingii (Cyanophyta). J. Appl. Phycol. 21, 279-285    

  Zuo, Y., Li, L., Wu, Z., and Song, L. (2009) Isolation, identification and odour-producing abilities of geosmin/2-MIB in actinomycetes from sediments in Lake Lotus, China. J. Water Supply: Res. Technol.--AQUA 58, 552-561     

  Chen, W., Song, L., Peng, L., Wan, N., Zhang, X., and Gan, N. (2008) Reduction in microcystin concentrations in large and shallow lakes: Water and sediment-interface contributions. Water Res. 42, 763-773     

  Hu, C., Gan, N., He, Z., and Song, L. (2008) A novel chemiluminescent immunoassay for microcystin (MC) detection based on gold nanoparticles label and its application to MC analysis in aquatic environmental samples. Int. J. Environ. Anal. Chem. 88, 267-277     

  Wan, N., Song, L., Wang, R., and Liu, J. (2008) Spatio-temporal distribution of algal biomass in Dianchi Lake and its impact factors. Shuisheng Shengwu Xuebao 32, 184-188     

  Wei, L., Sun, B., Song, L., and Nie, P. (2008) Gene expression profiles in liver of zebrafish treated with microcystin-LR. Environ. Toxicol. Pharmacol. 26, 6-12     

  Hou, G., Li, H., Recknagel, F., and Song, L. (2007) Using the moving window incorporated neural network to forecast the population behavior of Nostocales spp. in the River Darling, Australia. Fresenius Environ. Bull. 16, 304-309   

  Li, H., Hou, G., Song, L., and Liu, Y. (2007) Modeling algal blooms in Lake Dianchi, China using neural networks. Fresenius Environ. Bull. 16, 798-803     

  Shen, H., and Song, L. (2007) Comparative studies on physiological responses to phosphorus in two phenotypes of bloom-forming Microcystis. Hydrobiologia 592, 475-486   

  Song, L., Chen, W., Peng, L., Wan, N., Gan, N., and Zhang, X. (2007) Distribution and bioaccumulation of microcystins in water columns: a systematic investigation into the environmental fate and the risks associated with microcystins in Meiliang Bay, Lake Taihu. Water Res. 41, 2853-2864     

  Chen, W., Li, L., Gan, N., and Song, L. (2006) Optimization of an effective extraction procedure for the analysis of microcystins in soils and lake sediments. Environ. Pollut. (Amsterdam, Neth.) 143, 241-246     

  Chen, W., Song, L., Gan, N., and Li, L. (2006) Sorption, degradation and mobility of microcystins in Chinese agriculture soils: Risk assessment for groundwater protection. Environ. Pollut. (Amsterdam, Neth.) 144, 752-758     

  Liu, Y., Chen, W., Li, D., Shen, Y., Liu, Y., and Song, L. (2006) Analysis of paralytic shellfish toxins in Aphanizomenon DC-1 from Lake Dianchi, China. Environ. Toxicol. 21, 289-295     

  Zeng, H., Song, L., Yu, Z., and Chen, H. (2006) Distribution of phytoplankton in the Three-Gorge Reservoir during rainy and dry seasons. Sci. Total Environ. 367, 999-1009     

  Zhao, M., Xie, S., Zhu, X., Yang, Y., Gan, N., and Song, L. (2006) Effect of dietary cyanobacteria on growth and accumulation of microcystins in Nile tilapia (Oreochromis niloticus). Aquaculture 261, 960-966 


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