Location:Home >>Scientist >> Faculty
Contact Information
Name  
Bingsheng ZHOU
Academic Title  
  Professor
Education  
  Ph.D.
Phone  
  86-27-68780042
 E-mail 
  bszhou@ihb.ac.cn

Personal Profile:

Personal Data:
Dr. Bingsheng Zhou, studied his Bachelor and Master's degree at Wuhan University, China and doctorate at City University of Hong Kong, HK SAR, China. He took up his post-doctoral training at the Department of Biology, McMaster University, Canada, then he returned to Hong Kong as a Research Fellow and worked in the Center for Marin Environmental Research and Innovation Technology, City University of Hong Kong. He jointed the Institute of Hydrobiology, Chinese Academy of Sciences (CAS) in December 2004.

Dr. Zhou's main research interests primary focus on environmental toxicology at all levels from the molecular to the ecological. Specific research examines persistent organic pollutants (POPs) and endocrine disrupted chemicals, in particularly studies in the molecular mechanisms of toxicant-exposed model animals, cell lines and primary cultured cells, and effects of POPs on reproduction, growth, development, genetic toxicity, and developing biomarkers for early warning for the aquatic environments.

Research Experience:

July, 1989-Sep, 1995: Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, Research Assistant and Assistant Professor.

Sep, 1995-Oct, 1996: Department of Biology and Chemistry, City University of Hong Kong, Research Assistant.

Feb, 2001-June, 2001: The Center for Coastal Pollution and Conservation, City University of Hong Kong, Research Fellow.

July, 2001-June, 2003: Department of Biology, McMaster University, Canada, Post- doctoral Fellow.

June, 2003-Dec, 2004: The Center for Marin Environmental Research and Innovation Technology, City University of Hong Kong, Research Fellow.

Dec, 2004-Present: Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, Principle Investigator, Professor of Biology.


Research Directions:
Environmental Toxicology and Risk Assessment
Social Titles:

Awards & Honors:
Recent Publications:

1. Li R, Zhou P*, Guo Y, Lee JS, Zhou B*, 2017. Tris (1, 3-dichloro-2-propyl) phosphate-induced apoptotic signaling pathways in SH-SY5Y neuroblastoma cells. NeuroToxicology 58, 1-10.

2. Li R, Zhou P*, Guo Y, Lee JS, Zhou B*, 2017. Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways. Food & Chemical Toxicology 100, 183-196.

3. Chen L, Au DWT, Hu C, Peterson DR, Zhou B* and Qian PY*, 2017. Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity. Environmental Science &Technology 51, 1840-1847.

4. Ruiwen Li, Peijiang Zhou*, Yongyong Guo, Bingsheng Zhou*, 2017.The involvement of autophagy and cytoskeletal regulation in TDCIPP-induced SH-SY5Y cell differentiation. NeuroToxicology 62, 14–23.

5. Lianguo Chen, Xianfeng Wang, Xiaohua Zhang, Paul K.S. Lam, Yongyong Guo, James C.W. Lam*, Bingsheng Zhou*, 2017. Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution 230, 96-106.

6. Hua J, Han J, Wang X, Guo Y, Zhou B*, 2016. The binary mixtures of megestrol acetate and 17a-ethynylestradiol adversely affect zebrafish reproduction. Environmental Pollution 213, 776-784.

7. Lianguo Chen, Biran Zhu, Yongyong Guo, Tao Xu, Jae-Seong Lee, Pei-Yuan Qian, Bingsheng Zhou*, 2016. High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE- 209) and lead, in zebrafish larvae. Environmental Pollution 214, 324-333.

8. Qi Fang, Qipeng Shi, Yongyong Guo, Jianghuan Hua, Xianfeng Wang, Bingsheng Zhou*, 2016. Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish. Environmental Science &Technology 50, 1005-1013.

9. Biran Zhu, Qiangwei Wang, Xiongjie Shi, Yongyong Guo, Tao Xu, Bingsheng Zhou*, 2016. Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae. Chemosphere 144, 1646-1654.

10. Zhou B*, 2015. Adverse outcome pathway: Framework, application, and challenges in chemical risk assessment. Journal of Environmental Sciences 35, 191-193.

11. Jianghuan Hua, Jian Han, Yongyong Guo, Bingsheng Zhou*, 2015.The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations. Aquatic Toxicology 166, 1-9.

12. Qiangwei Wang#, Nelson Lok-Shun Lai#, Xianfeng Wang, Yongyong Guo, Paul Kwan-Sing Lam, James Chung-Wah Lam*, Bingsheng Zhou*, 2015. Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-dichloro 2-propyl phosphate (TDCPP) Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae. Environmental Science &Technology 49, 5123–5132.

13. Yongyong Guo, Yuanjin Yang, Yong Gao, Xianfeng Wang, Bingsheng Zhou*, 2015. The impact of long term exposure to phthalic acid esters on reproduction in Chinese rare minnow (Gobiocypris rarus). Environmental Pollution 203, 130-136.

14. Qiangwei Wang, James CW Lam, Jian Han, Xianfeng Wang, Yongyong Guo, Paul KS Lam, Bingsheng Zhou*, 2015. Developmental exposure to the organophosphorus flame retardant Tris(1,3-dichloro-2-propyl) phosphate: estrogenic activity, endocrine disruption and reproductive effects on zebrafish. Aquatic Toxicology 160, 163–171.

15. Xianfeng Wang, Lihua Yang, Yuanyuan Wu, Changjiang Huang, Qiangwei Wang, Jian Han, Yongyong Guo, Xiongjie Shi, Bingsheng Zhou*, 2015. The developmental neurotoxicity of PBDEs: Effect of DE-71 on dopamine in zebrafish larvae. Environmental Toxicology & Chemistry 34, 1119–1126.

16. Qi Fang, Xiongiie Shi, Liping Zhang, Qiangwei Wang, Xianfeng Wang, Yongyong Guo, Bingsheng Zhou*, 2015. Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae. Journal of Hazardous Materials 283, 897-904.

17. Qiangwei Wang, James Chung-Wah Lam, Yin-Chung Man, Nelson Lok-Shun Lai, Karen Ying Kwok, Yong yong Guo, Paul Kwan-Sing Lam, and Bingsheng Zhou*, 2015. Bioconcentration, Metabolism and Neurotoxicity of the Organophorous Flame Retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to Zebrafish. Aquatic Toxicology 158, 108-115.

18. Biran Zhu, Qiangwei Wang, Xianfeng Wang, Bingsheng Zhou*, 2014. Impact of co-exposure of lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Aquatic Toxicology 157, 186-195.

19. Jian Han, Qiangwei Wang, Xianfeng Wang, Yonggang Li, Sheng Wen, Shan Liu, Guangguo Ying, Yongyong Guo, Bingsheng Zhou*, 2014. Impact of the synthetic progestin megestrol acetate on zebrafish reproduction. Aquatic Toxicology 150, 66-72.

20. Liqin Yu, Chunsheng Liu, Qi Chen, Bingsheng Zhou*, 2014. Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71. Environmental Toxicology & Chemistry 33, 1354–1362.

21. Wang Q#, Chen Q#, Zhou P, Li W, Wang J, Huang C, Wang X, Lin K, Zhou B*, 2014. Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae. Nanotoxicology 8 (S1), 196–207.

22. Guo Y, Zhou B*, 2013. Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay. Aquatic Toxicology 142–143, 138-145.

23. Wang X, Yang Y, Zhang L, Ma Y, Han J, Yang L, Zhou B*, 2013. Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow (Gobiocypris rarus). Environmental Toxicology & Chemistry 32, 1846-1854.

24. Chen L, Huang Y, Huang C, Hu B, Hu C, Zhou B*, 2013. Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae. Environmental Toxicology & Chemistry 32, 1370-1375.

25. Wang Q, Liang K, Liu J, Yang L, Guo Y, Liu C*, Zhou B*, 2013. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquatic Toxicology 126, 207-213.

26. Chen L, Huang C, Hu C, Ke Y, Yang L, Zhou B*, 2012. Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental Toxicology & Chemistry 31, 2338-2344.

27. Chen L#, Yu K#, Huang C, Yu L, Zhu B, PKS Lam, JCW Lam*, Zhou B*, 2012. Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology 46, 9727-9734.

28. Ma Y, Han J, Guo Y, Lam PKS, Wu RSS, Giesy JP, Zhang X, Zhou B*, 2012. Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol. Aquatic Toxicology 106-107, 173-181.

29. Chen Q, Yu L, Yang L, Zhou B*, 2012. Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae. Aquatic Toxicology 110-111, 141-148.

30. Chen L, Hu C, Huang C, Wang Q, Wang X, Yang L, Zhou B*, 2012. Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquatic Toxicology 120–121, 11–18.

31. Ma Y, Han J, Guo Y, Lam PKS, Wu RSS, Giesy JP, Zhang X, Zhou B*, 2011. Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology 282, 146–153.

32. Yu L#, Lam JCW#, Guo Y, Wu RSS, Lam* PKS, Zhou B*, 2011. Parental transfer of PBDEs and thyroid endocrine disruption in zebrafish. Environmental Science & Technology 45, 10652–10659.

33. Liu C, Zhang X, Deng J, Hecker M, AL-Khedhairy A, Giesy JP, Zhou B*, 2011. Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA and HPT Axes in zebrafish. Environmental Science & Technology 45, 769–775.

34. Liu C, Zhang X*, Chang H, Jones P, Wiseman S, Naile J, Hecker M, Giesy JP, Zhou B*, 2010. Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP signaling cascade. Toxicology & Applied Pharmacology 247, 222-228.

35. Shi X, Zhou B*, 2010. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicological Sciences 115, 391 – 400.

36. Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B*, 2010. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae. Aquatic Toxicology 97, 226-233.

37. Liu C, Deng J, Yu L, Ramesh M, Zhou B*, 2010. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Aquatic Toxicology 96, 70-76.

38. Deng J, Liu C, Yu L, Zhou B*, 2010. Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction. Toxicology & Applied Pharmacology 243, 87-95.

39. Shi X, Yeung LWY, Lam PKS, Wu RSS, Zhou B*, 2009. Protein Profiles in Zebrafish (Danio rerio) Embryos Exposed to PFOS. Toxicological Sciences 110, 334-340. 

40. Deng J, Yu L, Liu C, Yu K, Shi X, Yeung L, Lam PKS, Wu RSS, Zhou B*, 2009. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquatic Toxicology 93, 29-36.

41. Liu C, Yu L, Deng J, Lam PKS, Wu RSS, Zhou B*, 2009. Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic–pituitary–gonadal (HPG) axis of zebrafish. Aquatic Toxicology 93, 131-137.

42. Du Y, Shi X, Liu C, Yu K, Zhou B*, 2009. Chronic effects of waterborne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: a partial life-cycle test. Chemosphere 74, 723-729.

43. Yu K, He Y, Yeung LWY, Lam PKS, Wu RSS, Zhou B*, 2008. DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicological Sciences 104, 341-351.

44. Shi X, Du Y, Lam PKS, Wu RSS, Zhou B*, 2008. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicology & Applied Pharmacology 230, 23-32.

45. Liu C, Du Y, Zhou B*, 2007. Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic Toxicology 85, 267-277.

46. Ding L, Murphy MB, He Y, Xu Y, Yeung LWY, Wang J, Zhou B*, Lam PKS, Wu RSS, Giesy JP, 2007. Effects of brominated flame retardants and brominated dioxins on steroidgenesis in H295R cells. Environmental Toxicology & Chemistry 26, 764-772.

47. Liu C, Yu K, Shi X, Wang J, Lam PKS, Wu RSS, Zhou B*, 2007. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology 82, 135-143.

48. Zhou B*, Liu C, Wang J, Lam PKS, Wu RSS, 2006. Primary cultured cells as sensitive in vitro model for assessment of toxicants-comparison to hepatocytes and gill epithelia. Aquatic Toxicology 80, 109-118.


Grants & Research Projects: