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姓 名:
 张奇亚
性 别:
 女
职 称:
 研究员
学 历:
 研究生
电 话:
 86-27-68780792
电子邮件:
 zhangqy@ihb.ac.cn

简历:

    张奇亚 博士,中国科学院水生生物所二级研究员,博士生导师。
    武汉大学理学学士,美国俄亥俄医学院 (Medical College of Ohio, MCO) 医学硕士,中国科学院水生生物研究所理学博士。先后在中国科学院武汉病毒研究所、美国俄亥俄医学院、美国加州大学圣迭戈分校 (University of California,San Diego, UCSD) 和中国科学院水生生物研究所从事病毒学及分子生物学相关领域的研究工作。兼国际病毒分类委员会委员,湖北省电镜学会副理事长和省微生物学会理事。已发表论文200余篇,其中SCI论文100余篇;主著(编)论著2部,参编论著10余部。获国家授权发明专利6项,获湖北省自然科学二等2项奖、中国科学院教学成果二等奖、中国科学院优秀研究生导师奖和中国科学院朱李月华优秀教师奖。培养博士后4名,毕业研究生34名 (含博士22名),其中2篇学位博士论文入选“湖北省优博论文”,5人次获“研究生国家奖”;多数研究生获其他冠名奖、三好学生奖、优秀毕业生奖等。
    主持的学科组长期从事水生病毒及其分子生物学研究。结合现代生物技术与病毒学方法,运用和/或创建水生病毒重组、多组学与高通量筛选、荧光显微与电子显微、分子免疫及病毒入侵示踪等技术,对水生病毒的病原生物学及分子特性进行研究。



研究方向:
水生病毒学及其分子生物学 
职务:

社会任职:

获奖及荣誉:

湖北省自然科学二等奖2项 (2004, 2017)

中国科学院教学成果二等奖 (2008) 

获中国科学院朱李月华优秀教师奖 (2009)

湖北省优秀博士学位论文指导教师奖2次 (2009, 2012)

   
代表论著:

主著中英文双语论著Zhang QY, Gui JF. 2012. Atlas of Aquatic Viruses and Viral Diseases. Science Press, Beijing, pp1-479  [张奇亚 桂建芳 . 2012.《水生病毒与病毒病图鉴》. 科学出版社, 北京, 1-479]

主编研究生教材:张奇亚, 桂建芳 编著. 2008.《水生病毒学》, 高等教育出版社, 北京, 1-414

 

参编英文专著

Gray MJChinchar VG (eds). 2015. Ranaviruses Lethal Pathogens of Ectothermic Vertebrates. Springer. Pp 105-139

Gui JF, Tang QS, Li ZJ, Liu JS, Silva SSDe (eds). 2018. Chinese Aqaculture: Succes Stories and Modern Trends. Chichester, UK: Wiley UK. Pp 577-598

 

5年发表的部分论文题录:

Ke F, Gui JF, Chen ZY, Li T, Lei CK, Wang ZH, Zhang QY. 2018. Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander. BMC Genomics. 19(1):211

Chen ZY, Li T, Gao XC, Wang CF, Zhang QY. 2018. Protective Immunity Induced by DNA Vaccination against Ranavirus Infection in Chinese Giant Salamander Andrias davidianus. Viruses. 10(2). pii: E52

Cao YS, Wang D, Li SW, Xu LM, Zhao JZ, Liu HB, Lu TY, Zhang QY. 2018. Identification and analysis of differentially expressed microRNAs in rainbow trout (Oncorhynchus mykiss) responding to infectious hematopoietic necrosis virus infection. Developmental and Comparative Immunology, 88(2018):28-36

Gui L, Chinchar VG, Zhang QY. 2018. Molecular basis of pathogenesis of emerging viruses infecting aquatic animals. Aquaculture and Fisheries. 3(1)1-5

Gui L, Li T, Zhang QY. 2018. Fish kidney cells show higher tolerance to hyperosmolality than amphibian. Aquaculture and Fisheries. 3(3): 135-138

Mao MG, Jiang JL, Jiang ZQ, Liu RT, Zhang QY, Gui JF. 2018. Molecular characterization of caspase members and expression response to Nervous Necrosis Virus outbreak in Pacific cod. Fish & Shellfish Immunology 74: 559–566 

Gao FX, Lu WJ, Wang Y, Zhang QY, Zhang YB, Mou CY, Li Z, Zhang XJ, Liu CW, Zhou L, Gui JF. 2018. Differential expression and functional diversification of diverse immunoglobulin domain-containing protein (DICP) family in three gynogenetic clones of gibel carp. Developmental & Comparative Immunology, 84:396-407

Mou CY, Wang Y, Zhang QY, Gao FX, Li Z, Tong JF, Zhou L, Gui JF, 2018. Differential interferon system gene expression profiles in susceptible and resistant gynogenetic clones of gibel carp challenged with herpesvirus CaHV. Developmental & Comparative Immunology, 86: 52-64

Chinchar VG,  Hick P, Ince IA, Jancovich JK, Marschang R, Qin Q, Subramaniam K, Waltzek TB, Whittington R, Williams T, Zhang QY, Ictv Report Consortium. 2017. ICTV Virus Taxonomy Profile: Iridoviridae. Journal of General Virology. 98(5):890-891

Cao YSZhang QY, Xu LM, Lia SW, Wang D, Zhao JZ, Liu HB, Feng J, Lu TY. 2017. Effects of different cytokines on the immune responses of rainbow trout (Oncorhynchus mykiss) in a virus DNA vaccination model. Oncotarget. 8(68): 112222-112235

Gao FX,Wang Y, Zhang QY, Mou CY, Li Z, Deng YS, Zhou L, Gui JF. 2017. Distinct herpesvirus resistances and immune responses of three gynogenetic clones of gibel carp revealed by comprehensive transcriptome. BMC Genomics, 18:561

Zeng XT, Chen ZY, Deng YS, Gui JF, Zhang QY. 2016. A novel fish herpesvirus genome without terminal direct repeat and its molecular diagnosis. Archives of Virology. 161(12):3577-3581

Liu J, Pei C, Gao X, Chen ZY, Zhang QY. 2016. Fish reovirus GCRev-109 VP33 protein elicits protective immunity in rare minnows. Archives of Virology. 161(3):573-82  

Cao YS, Xu LM. LaPatra SE, Zhao JZ, Liu M, Liu HB, Lu TY, Zhang QY. 2016. The kinetics and protection of the antiviral state induced by recombinant iIFN1a in rainbow trout against infectious hematopoietic necrosis virus. Molecular Immunology. 76:55-61 

Wang J, Gui L, Chen ZY, Zhang QY. 2016. Mutations in the C-terminal region affect subcellular localization of crucian carp herpesvirus (CaHV) GPCR. Virus Genes. 52:484-494  

Gao XC, Chen ZY, Liu J, Zhang QY. 2016. Development and application of monoclonal antibodies for detection and analysis of aquareoviruses. Journal of Immunoassay and Immunochemistry. 37(4): 376-389  

Huang X, Fang J, Chen ZY, Zhang, QY. 2016. Rana grylio virus TK and DUT gene locus could be simultaneously used for foreign gene expression. Virus Research, 214: 33-38 

Gao XC, Chen ZY, Liu J, Zhang QY. 2016. Development and application of monoclonal antibodies for detection and analysis of aquareoviruses. J Immunoassay Immunochem 37 (4): 376-389

Gui L, Zhang PP, Zhang QY, Zhang JB. 2016. Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in vitro. Fish & Shellfish Immunology 50: 191-199

Xu D, Xia SY, Podok P, Xie J, Zhang QY,, Lu LQ. 2016. Characterization of IκBa, Rab21 and Rac2 as Innate Immune Genes during Infection with Aeromonas hydrophila and Cyprinid herpesvirus 2 in Crucian Carp Carassius auratus gibelioFish Pathology, (51):S7–S19

Zhang QY, Gui JF. 2015. Virus genomes and virus-host interactions in aquaculture animals. Sci China Life Sci. 58(2): 156–169 

Gao XC, Chen ZY, Yuan JD, Zhang QY. 2015. Morphological changes in amphibian and fish cell lines infected with Andrias davidianus ranavirus. Journal of Comparative Pathology. 152(2-3):110-113 

Ou T, Liao XY, Gao XC, Xu XD, Zhang QY. 2015. Unraveling the genome structure of cyanobacterial podovirus A-4L with long direct terminal repeats. Virus Research. 203:4-9  

Yuan JD, Chen ZY, Huang X, Gao XC, Zhang QY. 2015. Establishment of three cell lines from Chinese giant salamander and their sensitivities to the wild-type and recombinant ranavirus. Veterinary Research. 46:58 

Chen ZY, Gao XC, Zhang QY. 2015. Whole-genome analysis of a novel fish reovirus (MsReV) discloses aquareovirus genomic structure relationship with host in saline environments. Viruses. 7(8): 4282-4302   

Ou T, Gao XC, Li SH, Zhang Q. 2015. Genome analysis and gene nblA identification of Microcystis aeruginosa myovirus (MaMV-DC) reveal the evidence for horizontal gene transfer events between cyanomyovirus and host.  Journal of General Virology. 96:3681-3697 

Feng H, Zhang YB, Zhang QM, Li Z, Zhang QY, Gui JF. 2015. Zebrafish IRF1 Regulates IFN Antiviral Response through Binding to IFN?1 and IFN?3 Promoters Downstream of MyD88 Signaling. J Immunol. 194 (3):1225-38

He LB, Ke F, Wang J, Gao XC, Zhang QY. 2014. Rana grylio virus (RGV) envelope protein 2L subcellular localization and essential roles in virus infectivity revealed by conditional lethal mutant. Journal of General Virology, 95: 679-690 

Zhu RL, Zhang QY. 2014. Determination and analysis of the complete genome sequence of Paralichthys olivaceus rhabdovirus (PORV). Archives of Virology. 159: 817-820  

Pei C, Ke F, Chen ZY, Zhang QY. 2014. Complete genome sequence and comparative analysis of grass carp reovirus strain 109 (GCReV-109) with other grass carp reovirus strains reveals no significant correlate regional distribution. Archives of Virology. 159: 2435-2440   

Ou T, Lei XY, He LB, Zhou FJ, Zhang QY. 2014. Development of an Ussuri catfish Pseudobagrus ussuriensis skin cell line displaying differential cytopathic effects to three aquatic animal viruses. Virus Research. 189: 56-62   

Zhu R, Chen ZY, Wang J, Yuan JD, Liao XY, Gui JF, Zhang QY Extensive diversification of MHC in Chinese giant salamanders Andrias davidianus (Anda-MHC) reveals novel splice variants. Developmental & Comparative Immunology, 2014, 42: 311-322 

Zhu R, Chen ZY, Wang J, Yuan JD, Liao XY, Gui JF, Zhang QY. 2014. Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander (Andrias davidianus). Developmental & Comparative Immunology. 46(2): 413-422

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