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姓 名:
 葛峰
性 别:
 男
职 称:
 研究员
学 历:
 研究生
电 话:
 86-27-68780500
电子邮件:
 gefeng@ihb.ac.cn

简历:

葛峰,男,博士,博士生导师, 中国科学院水生生物研究所所水生生物蛋白质组学科组组长,山东大学学士,中科院武汉病毒所硕士,新加坡国立大学博士。多年来从事功能蛋白质组学领域相关的研究工作,以重要水生模式生物为研究对象;发展基于质谱的定量蛋白质组学方法和重要翻译后修饰的鉴定技术;以水生生物的翻译后修饰组学和蛋白基因组学为研究核心和特色;开展水生生物的功能蛋白质组学研究;推动水生生物蛋白质组学这一新的研究领域的发展并解决水生生物研究中的一些重大科学问题。近年来在PNAS,Molecular Plant, Plant Cell, Molecular and Cellular Proteomics, Journal of Proteome Research等国际专业杂志发表通讯作者论文40 多篇。担任Journal of Integrated Omics , Current Proteomics等国际专业杂志编辑(Associate Editor)。作为课题负责人承担有国家重点研发计划项目、国家自然科学基金面上和重大研究计划项目、中科院先导B等多项课题研究。目前的研究兴趣主要集中在(1) 蛋白质翻译后修饰组学及其功能研究 (2) 非编码RNA与蛋白质相互作用网络及其调控机制 (3)重要模式生物的蛋白基因组学(Proteogenomics)分析。



研究方向:
功能蛋白质组学
职务:

社会任职:

获奖及荣誉:
代表论著:

1: Mingkun Yang, Xiaohuang Lin, Xin Liu, Jia Zhang, Feng Ge*. Genome annotation of a model diatom Phaeodactylum tricornutum using an integrated proteogenomic pipeline. Molecular Plant. In Press. DOI: 10.1016/j.molp.2018.08.005. *通讯作者)

2: Liu X, Yang M, Wang Y, Chen Z, Zhang J, Lin X, Ge F*, Zhao J*. Effects of PSII Manganese-Stabilizing Protein Succinylation on Photosynthesis in the Model Cyanobacterium Synechococcus sp. PCC 7002. Plant and Cell Physiology. 2018 Jul 1;59(7):1466-1482. *通讯作者)

3: Ren S, Yang M, Yue Y, Ge F, Li Y, Guo X, Zhang J, Zhang F, Nie X, Wang S. Lysine Succinylation Contributes to Aflatoxin Production and Pathogenicity in Aspergillus flavus. Molecular & Cellular Proteomics. 2018 Mar;17(3):457-471.

4: Wu Y, Xiong Q, Li S, Yang X, Ge F*. Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr). Molecular & Cellular Proteomics. 2018 Jan; 17(1): 146-159. *通讯作者)

5: Yang X, Xiong Q, Wu Y, Li S, Ge F*. Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells. Journal of Proteome Research. 2017 Oct 6;16(10):3891-3902. *通讯作者)

6: Chen, Zhuo; Zhang, Guiying; Yang, Mingkun; Li, Tao*; Ge, Feng*; Zhao, Jindong. Lysine Acetylome Analysis Reveals Photosystem II Manganese-stabilizing Protein Acetylation is Involved in Negative Regulation of Oxygen Evolution in Model Cyanobacterium Synechococcus sp. PCC 7002. Molecular & Cellular Proteomics. 2017;16(7):1297-1311.*通讯作者)

7: Ma, Yanyan; Yang, Mingkun; Lin, Xiaohuang; Liu, Xin; Huang, Hui; Feng Ge*. Malonylome Analysis Reveals the Involvement of Lysine Malonylation in Metabolism and Photosynthesis in Cyanobacteria. Journal of Proteome Research. 2017;16(5):2030-2043. *通讯作者)

8: Jia Zhang, Ming-kun Yang, Honghui Zeng, and Feng Ge*. GAPP: A Proteogenomic Software for Genome Annotation and Global Profiling of Post-translational Modifications in Prokaryotes. Molecular & Cellular Proteomics. 2016;15(11):3529-3539. *通讯作者)

9: 吴英; 熊倩; 葛峰*. 长链非编码RNA HOTAIR在细胞增殖中的作用机制. 生命科学. 2016, 28: 6; 680-685. (*通讯作者)

10: Wu Y, Lou QY, Ge F, Xiong Q.*. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Scientific Reports. 2017; 7(1):4022.*通讯作者)

11: Ren S, Yang M, Li Y, Zhang F, Chen Z, Zhang J, Yang G, Yue Y, Li S, Ge F*, Wang S.*. Global Phosphoproteomic Analysis Reveals the Involvement of Phosphorylation in Aflatoxins Biosynthesis in the Pathogenic Fungus Aspergillus flavus. Scientific Reports. 2016; 6: 34078.*通讯作者)

12: Siting Li, Minghai Chen, Qian Xiong, Jia Zhang, Zongqiang Cui, Feng Ge*. Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer Cells. Journal of Proteome Research. 2016, 7;15(10):3741-3751. *通讯作者)

13: 杨明坤;林小煌;马炎炎;王炎;葛峰*. 蓝藻的蛋白质翻译后修饰研究进展. 水生生物学报,2016 (05)1056-1067. (*通讯作者)

14: Ming-kun Yang, Yao-hua Yang, Zhuo Chen, Jia Zhang, Yan Lin, Yan Wang, Qian Xiong, Tao Li*, Feng Ge*, Donald A. Bryant, and Jin-dong Zhao. Proteogenomic analysis and global discovery of post-translational modifications in prokaryotes. Proceedings of the National Academy of Sciences of the United States of America201411152):E5633-E5642*通讯作者)

15: Peng ZhengQian XiongYing WuYing ChenZhuo ChenJoy FlemingDing GaoLijun BiFeng Ge*Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Non-coding RNA HOTAIR in HeLa CellsMolecular & Cellular Proteomics, 2015, 14 (5) :1447-63. *通讯作者)

16: Feng Ge, Weichao Huang, Zhuo Chen, Chunye Zhang, Qian Xiong, Chris Bowler, Juan Yang, Jin Xu, and Hanhua Hu. Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum Plant Cell 2014; 26(4):1681-1697.

17: Ziyad Tariq Muhseen, Qian Xiong, Zhuo Chen and Feng Ge*. Proteomics studies on stress responses in diatoms. Proteomics. 2015;15(23-24):3943-53.*通讯作者)

18: Zhuo Chen, Jiao Zhan, Ying Chen, Mingkun Yang, Chenliu He, Feng Ge*, Qiang Wang*. Effects of Phosphorylation of β Subunits of Phycocyanins on State Transition in the Model Cyanobacterium Synechocystis sp. PCC 6803. Plant and Cell Physiology. 2015, 56 (10): 1997-2013. *通讯作者)

19: Qian Xiong, Zhuo Chen, Feng Ge*. Proteomic analysis of post translational modifications in cyanobacteria. Journal of Proteomics. 2016; 134:57-64.*通讯作者)

20: Mingkun Yang, Yan Wang, Ying Chen, Zhongyi Cheng, Jing Gu, Jiaoyu Deng, Lijun Bi, Chuangbin Chen, Ran Mo, Xude Wang, and Feng Ge*. Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis H37Rv. Molecular & Cellular Proteomics201514 (4): 796-811*通讯作者)

21: Qian XiongJie FengSi-ting LiGui-ying ZhangZhi-xian QiaoZhuo ChenYing WuHui HuangYan LinTao Li*Feng Ge*Jin-dong Zhao*. Integrated Transcriptomic and Proteomic Analysis of the Global Response of Synechococcus sp. PCC 7002 to High Light Stress. Molecular & Cellular Proteomics2015; 14(4): 1038-53*通讯作者)

22: Yang, YaohuaFeng, JieLi, Tao*Feng Ge*Zhao, Jindong. CyanOmics: an integrated database of omics for the model cyanobacterium Synechococcus sp. PCC 7002. Database (Oxford)2015 Jan 28;2015. pii: bau127. doi: 10.1093/database/bau127. *通讯作者)

23: Ran Mo, Mingkun Yang, Zhuo Chen, Zhongyi Cheng, Xingling Yi, Chongyang Li, Chenliu He, Qian Xiong, Hui Chen, Qiang Wang*, and Feng Ge*. Acetylome Analysis Reveals the Involvement of Lysine Acetylation in Photosynthesis and Carbon Metabolism in the Model Cyanobacterium Synechocystis sp. PCC 6803. Journal of Proteome Research 2015142: 1275-1286*通讯作者)

24: Fengying Liu, Mingkun Yang, Xude Wang, Shanshan Yang, Jing Gu, Jie Zhou, Xian-En Zhang*, Jiaoyu Deng*, and Feng Ge*. Acetylome analysis reveals diverse functions of lysine acetylation in Mycobacterium tuberculosis. Molecular & Cellular Proteomics 2014; 13(12):3352-66 *通讯作者)

25: Zhuo Chen, Ming-kun Yang, Chong-yang Li, Yan Wang, Jia Zhang, Dian-bing Wang, Xian-en Zhang*, and Feng Ge*. Phosphoproteomic Analysis Provides Novel Insights into Stress Responses in Phaeodactylum tricornutum, a Model Diatom. Journal of Proteome Research 2014; 13(5): 2511-23 *通讯作者)

26: Miao Tian, Xiulan Chen, Qian Xiong, Jie Xiong, Chuanle Xiao, Feng Ge*, Fuquan Yang*, and Wei Miao*. Phosphoproteomic analysis of protein phosphorylation networks in Tetrahymena thermophila, a Model Single-Celled Organism. Molecular & Cellular Proteomics 2014;13(2):503-19. *通讯作者)

27: Ying Chen, Li-Na Yang, Li Cheng, Shun Tu, Shu-Juan Guo, Huang-Ying Le, Qian Xiong, Ran Mo, Chong-Yang Li, Jun-Seop Jeong, Lizhi Jiang, Seth Blackshaw, Li-Jun Bi, Heng Zhu*, Sheng-Ce Tao*, and Feng Ge*. BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Molecular & Cellular Proteomics 2013;12(10):2804-19. *通讯作者)

28: Ming-kun Yang, Zhi-xian Qiao, Wan-yi Zhang, Qian Xiong, Jia Zhang, Tao Li*, Feng Ge*, and Jin-dong Zhao*. Global phosphoproteomic analysis reveals diverse functions of Serine/Threonine/Tyrosine phosphorylation in the model cyanobacterium synechococcus sp. strain PCC 7002. Journal of Proteome Research 2013, 12 (4), 1909–1923. *通讯作者)

29: Chongyang Li, Qian Xiong, Jia Zhang, Feng Ge* and Li-Jun Bi. Quantitative Proteomic Strategies for the Identification of MicroRNA Targets. Expert Review of Proteomics 2012;9(5):549-59 *通讯作者)

30: Qian Xiong, Qiu Zhong, Jia Zhang, Mingkun Yang, Chongyang Li, Peng Zheng, Li-Jun Bi*, and Feng Ge*. Identification of Novel miR-21 Target Proteins in Multiple Myeloma Cells by Quantitative Proteomics. Journal of Proteome Research 2012; 11(4):2078-90 *通讯作者)

31: Peng Zheng, Qiu Zhong, Qian Xiong, Mingkun Yang, Jia Zhang, Chongyang Li, Li-Jun Bi*, Feng Ge*. QUICK identification and SPR validation of signal transducers and activators of transcription 3 (Stat3) interacting proteins. Journal of Proteomics 2012; 75(3):1055-66. *通讯作者)

32: Jia Zhang, Fangjin Chen, Wenliang Li, Qian Xiong, Mingkun Yang, Peng Zheng, Chongyang Li, Jianfeng Pei*, Feng Ge*. 14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells. PLoS One 2012;7(1):e29554. *通讯作者)

33: Qian Xiong, Feng Ge*. Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients. Expert Review of Proteomics 2011;8(4):439-42 *通讯作者)

34: Feng Ge*, Li-Jun Bi, Sheng-Ce Tao, Xudong Xu, Zhi-Ping Zhang, Kaio Kitazato and Xian-En Zhang*. Proteomic analysis of multiple myeloma: current status and future perspectives. Proteomics Clin Appl 2011; 5:30-37. *通讯作者)

35: Feng Ge*, Shengce Tao, Lijun Bi, Zhiping Zhang, and Xianen Zhang*. Proteomics: addressing the challenges of multiple myeloma. Acta Biochim Biophys Sin (Shanghai) 2011; 43:89-95. *通讯作者)

36: Feng Ge*, Liang Zhang, Sheng-Ce Tao, Kaio Kitazato, Zhi-Ping Zhang, Xian-En Zhang, and Li-Jun Bi*. Quantitative proteomic analysis of tumor reversion in multiple myeloma cells. Journal of Proteome Research 2011;10(2):845-55. *通讯作者)

37: Feng Ge*, Wen-Liang Li, Li-Jun Bi, Sheng-Ce Tao, Zhi-Ping Zhang, and Xian-En Zhang. Identification of novel 14-3-3ζ interacting proteins by quantitative immunoprecipitation combined with knockdown (QUICK). Journal of Proteome Research 2010 Nov 5;9(11):5848-58. *通讯作者)

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