首页  书记信箱  网站地图  邮箱登陆  English  中国科学院
研究队伍
现在位置:首页 > 研究队伍 > 人才
姓 名:
 肖武汉
性 别:
 男
职 称:
 研究员
学 历:
 研究生
电 话:
 86-27-68780087
邮 箱:
 w-xiao@ihb.ac.cn

简历:

博士, 研究员, 1989年毕业于武汉大学, 获学士学位; 1997年在中国科学院水生生物研究所获博士学位。1994年至1998年在中国科学院水生生物研究所任助理研究员;1998年10月至2003年10月在美国西北大学(Northwestern University)做博士后, 任研究助理(Research Associate); 2003年10月至2005年12月在美国西北大学医学院任研究助理教授(Research Assistant Professor, Faculty member);从2005年12月开始,在中国科学院水生生物研究所任研究员; 2006年8月至10月在美国匹兹堡大学(University of Pittsburgh) 任研究顾问(Research Consultant)。 



研究方向:

1. 鱼类耐低氧的分子机制与耐低氧新品种培育的遗传基础。 

2. 鱼类抗病毒感染的分子机制与抗病新品种培育的遗传基础。 

3. 鱼类低氧胁迫反应与抗病毒先天免疫反应交互作用的分子机制。 

职务:

社会任职:

获奖及荣誉:
代表论著:

代表论著(*通讯作者) 

2020 

(1) Sijia Fan Jing WangGuangqing Yu Fangjing RongDawei ZhangChenxi Xu Juan DuZhi Li Gang Ouyang Wuhan Xiao*  . TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation. Journal of Biological Chemistry2020, doi: 10.1074/jbc.RA120.014538. 

(2) Zhi Li Sijia Fan Jing Wang Xiaoyun ChenQian Liao Xing Liu Gang OuyangHong Cao Wuhan Xiao* .  Zebrafish F-box protein fbxo3 negatively regulates antiviral response through promoting K27-Linked polyubiquitination of the transcription factors irf3 and irf7. Journal of Immunology, 2020,205(7):1897-1908. 

(3) Xiaolian Cai Ziwen Zhou, Junji Zhu Qian Liao Dawei Zhang Xing Liu Jing Wang Gang Ouyang , Wuhan Xiao* . Zebrafish hif-3α modulates erythropoiesis via regulation of gata-1 to facilitate hypoxia tolerance. Development, 2020, doi: 10.1242/dev.185116. 

(4) Guangqing Yu Xing Liu Dawei ZhangJing WangGang Ouyang Zhu ChenWuhan Xiao *. Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity. Development, 2020, 147(18): dev.194886. 

(5) Guangqing Yu Xiong Li Ziwen Zhou Jinhua Tang Jing WangXing LiuSijia Fan Gang OuyangWuhan Xiao * . Zebrafish phd3 negatively regulates antiviral responses via suppression of Irf7 transactivity Independent of its prolyl hydroxylase activity. Journal of Immunology, 2020, 205(4):1135-1146. 

(6)  Gang Ouyang Qian Liao Dawei Zhang Fangjing Rong Xiaolian CaiSijia Fan Junji Zhu Jing Wang Xing Liu Xueqin LiuWuhan Xiao * . Zebrafish NF-κB/p65 is required for antiviral responses. Journal of Immunology, 2020, 204(11):3019-3029. 

(7) Xing Liu Chunchun ZhuHuangyuan Zha Jinhua Tang Fangjing RongXiaoyun Chen Sijia Fan Chenxi Xu Juan DuJunji ZhuJing Wang Gang Ouyang Guangqing Yu Xiaolian Cai Zhu Chen Wuhan Xiao *.  SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO Journal, 2020, 39(11): e103285. 

(8) Junji Zhu, Xing Liu, Xiaolian Cai, Gang Ouyang, Sijia Fan, Jing Wang, Wuhan Xiao*. Zebrafish prmt7 negatively regulates antiviral response by suppressing the retinoic acid-inducible gene 1-like receptor signaling. FASEB Journal, 2020, 34(1):988-1000. 

(9) Junji Zhu Xing Liu Xiaolian Cai Gang Ouyang Huangyuan Zha Ziwen Zhou Qian Liao Jing Wang Wuhan Xiao*. Zebrafish prmt3 negatively regulates antiviral responses. FASEB Journal, 2020, doi: 10.1096/ fj.201902569R 

  

2019 

(10) Junji Zhu, Dawei Zhang, Xing Liu, Guangqing Yu, Xiaolian Cai, Chenxi Xu, Fangjing Rong, Gang Ouyang, Jing Wang, Wuhan Xiao*. Zebrafish prmt5 arginine methyltransferase is essential for germ cell development. Development, 2019, 146(20): dev179572.  

(11) Guangqing Yu, Xing Liu, Jinghua Tang, Chenxi Xu, Gang Ouyang, Wuhan Xiao*. Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in Immunology, 2019, 10: 1432.  

  

2018 

(12)  Xiaolian Cai, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Wuhan Xiao*. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Journal of Biological Chemistry, 2018, 293(40): 15370-15380.  

(13)  Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259. 

  

2017 

(14) Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017,45(22): 12700-12714.  

(15) Dawei Zhang, Jing Wang, Chi Zhou, Wuhan Xiao*. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Mechanisms of Development, 2017, 143:42-52.  

  

2016   

(16) Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749. 

(17) Xing Liu, Xiaolian Cai, Bo Hu, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705.  

(18) Yu Chen, Chi Zhou, Wei Ji, Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumor growth. Nature Communications, 2016, 7: 11057. 

  

2015 

(19) Xing Liu, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945.   

(20) Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790.  

(21) Zhichao Mei, Dawei Zhang, Bo Hu, Jing Wang, Xian Shen, Wuhan Xiao*. FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity. Journal of Biological Chemistry, 2015, 290(26): 16202-16214. 

(22) Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098.  

  

2014 

(23) Bo Hu, Wei Zhang, Xi Feng, Wei Ji, Xunwei Xie, Wuhan Xiao*. Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis, Developmental Biology, 2014, 388: 81-93.  

(24) Jing Wang, Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248.  

(25) Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1a transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099.  

(26) Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775.  

(27) Wei Ji, Jing Wang, Wei Zhang, Xing Liu, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195.   

  

2013 

(28) Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development, 2013, 140: 1067-1078.   

  

2011 

(29) Xiaoyang Wan, Bo Hu, Jing-xia Liu, Xi Feng, Wuhan Xiao*. Zebrafish mll gene is essential for hematopoiesis. Journal of Biological Chemistry, 2011, 286: 33345-33357  

(30) Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011, 30: 3397-3415.  

  

2009 

(31) Jiangang Zhou, Xi Feng, Bing Ban, Jing-xia Liu, Zhou Wang*, Wuhan Xiao*. The elongation factor ELL(Eleven-Nineteen Lysine-Rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. Journal of Biological Chemistry, 2009, 284(28):19142-19152.  

(32) Jing-xia Liu, Bo Hu, Yang Wang, Jianfang Gui, Wuhan Xiao*. Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. Journal of Biological Chemistry, 2009, 284(24):16679-16692.  

 

Copyright 2003 © 中国科学院水生生物研究所 All Rights Reserved
地址:武汉市武昌东湖南路77号 电话:027-68780839
鄂ICP备050003091