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姓 名:
 陈联国
性 别:
 男
职 称:
 研究员
学 历:
 研究生
电 话:
 
电子邮件:
 lchenam@ihb.ac.cn

简历:

  2008年9月,获中国海洋大学水产养殖专业学士学位;2012年9月,获中国科学院水生生物研究所环境毒理专业硕士学位;2016年11月,获香港科技大学海洋环境科学专业哲学博士学位。2016年9月至2018年9月,在香港城市大学海洋污染国家重点实验室从事博士后阶段研究。2018年9月通过人才引进计划进入中科院水生所工作,被聘为研究员、博士研究生导师。成立“环境污染与生态风险”学科组(Research Group of Environmental Pollution and Ecological Risk)并任学科组长,现担任中国毒理学会分析毒理专业委员会青年委员。

  主要研究环境典型有机污染物(包括溴代阻燃剂、抗污损化合物和全氟代化合物等)的环境污染、毒代动力学、以及对淡水与海洋生物的毒性效应与作用机理。揭示了环境污染物在内分泌干扰效应、神经毒性、微生物群落和表观遗传学等方面的毒性作用和机制,确定了污染物的分子结合靶点和关键分子起始事件,构建有害结局通路。 以第一/通讯作者身份在环境科学、毒理学领域国际主流刊物上发表SCI论文29篇,其中Environmental Science & Technology发表6篇。并于2013年获得香港科技大学理学院的Research Excellence Award。

   



研究方向:

环境污染物的生态毒理效应与致毒机制;污染物环境行为;毒理学研究新技术开发

职务:

社会任职:

获奖及荣誉:
代表论著:

#共同第一作者;*通讯作者

Environmental Science & Technology (IF: 6.653): 

1. Chen, L., Hu, C., Tsui, M.M.P., Wan, T., Peterson, D.R., Shi, Q., Lam, P.K.S., Au, D.W.T., Lam, J.C.W.,* Zhou, B.* Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate. Environmental Science & Technology 2018, 52, 4432–4439.

2. Chen, L., Zhang, W.,# Hua, J., Hu, C., Lai, N.L.S., Qian, P.Y., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysregulation of intestinal health by environmental pollutants: Involvement of the estrogen receptor and aryl hydrocarbon receptor. Environmental Science & Technology 2018, 52, 2323–2330. 

3. Chen, L., Au, D.W.T., Hu, C., Peterson, D.R., Zhou, B.,* Qian, P.Y.* Identification of molecular targets for 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in teleosts: New insight into mechanism of toxicity. Environmental Science & Technology 2017, 51, 1840–1847.

4. Chen, L., Zhang, W., Ye, R., Hu, C., Wang, Q., Seemann, F., Au, D.W.T., Zhou, B., Giesy, J.P., Qian, P.Y.* Chronic exposure of marine medaka (Oryzias melastigma) to 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) reveals its mechanism of action in endocrine disruption via the hypothalamus-pituitary-gonadal-liver (HPGL) axis. Environmental Science & Technology 2016, 50, 4492–4501.

5. Chen, L., Sun, J.,# Zhang, H., Au, D.W.T., Lam, P.K.S., Zhang, W., Bajic, V.B., Qiu, J.W., Qian, P.Y.* Hepatic proteomic responses in marine medaka (Oryzias melastigma) chronically exposed to antifouling compound butenolide [5-octylfuran-2(5H)-one] or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Environmental Science & Technology 2015, 49, 1851–1859.

6. Chen, L., Yu, K.,# Huang, C., Yu, L., Zhu, B., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology 2012, 46, 9727–9734.

Environmental Science & Technology Letters (IF: 5.869):

7. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Wang, Q., Giesy, J.P., Lam, P.K.S. Perfluorobutanesulfonate exposure causes durable and transgenerational dysbiosis of gut microbiota in marine medaka. Environmental Science & Technology Letters 2018, 5, 731–738.

Environmental Pollution (IF: 4.358):

8. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Wang, Q., Hu, C., Wai, O.W.H., Zhou, B., Lam, P.K.S. Contamination by perfluoroalkyl substances and microbial community structure in Pearl River Delta sediments. Environmental Pollution 2019, 245, 218-225.

9. Chen, L., Hu, C., Lai, N.L.S., Zhang, W., Hua, J., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Acute exposure to PBDEs at an environmentally realistic concentration causes abrupt changes in the gut microbiota and host health of zebrafish. Environmental Pollution 2018, 240, 17-26.

10. Chen, L., Guo, Y., Hu, C., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish. Environmental Pollution 2018, 234, 307–317. 

11. Chen, L., Wang, X., Zhang, X., Lam, P.K.S., Guo, Y., Lam, J.C.W.,* Zhou, B.* Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution 2017, 230, 96–106.

12. Chen, L., Zhu, B., Guo, Y., Xu, T., Lee, J.-S., Qian, P.Y., Zhou, B.* High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae. Environmental Pollution 2016, 214, 324–333.

Science of the Total Environment (IF: 4.610):

13. Guo, Y., Chen, L.,# Wu, J., Hua, J., Yang, L., Wang, Q., Zhang, W., Lee, J.S., Zhou, B.* Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring. Science of the Total Environment 2019, 650, 557-565.

14. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S. Variation in microbial community structure in surface seawater from Pearl River Delta: Discerning the influencing factors. Science of the Total Environment 2019, 660, 136-144.

Aquatic Toxicology (IF: 3.884):

15. Chen, L., Tsui, M.M.P., Shi, Q., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S.,* Lam, J.C.W.* Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure. Aquatic Toxicology 2018, 201, 1–10.

16. Chen, L., Au, D.W.T., Hu, C., Zhang, W., Zhou, B., Cai, L., Giesy, J.P., Qian, P.Y.* Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3′-diindolylmethane (DIM). Aquatic Toxicology 2017, 183, 135–143.

17. Chen, L., Ye, R., Xu, Y., Gao, Z., Au, D.W.T., Qian, P.Y.* Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma). Aquatic Toxicology 2014, 149, 116–125.

18. Chen, L., Zhang, H.,# Sun, J., Wong, Y.H., Han, Z., Au, D.W.T., Bajic, V.B., Qian, P.Y.* Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Aquatic Toxicology 2014, 157, 47–56.

19. Chen, L., Hu, C., Huang, C., Wang, Q., Wang, X., Yang, L., Zhou, B.* Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquatic Toxicology 2012, 120–121, 11–18.

Journal of Environmental Sciences (IF: 3.120):

20. Chen, L.,* Lam, J.C.W. SeaNine 211 as antifouling biocide: A coastal pollutant of emerging concern. Journal of Environmental Sciences 2017, 61, 68–79. 

Chemosphere (IF: 4.427):

21. Chen, L.,* Hu, C., Guo, Y., Shi, Q., Zhou, B. TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure. Chemosphere 2019, 217, 732-741.

22. Chen, L., Xu, Y., Wang, W., Qian, P.Y.* Degradation kinetics of a potent antifouling agent, butenolide, under various environmental conditions. Chemosphere 2015, 119, 1075–1083.

Chemical Research in Toxicology (IF: 3.432):

23. Chen, L., Ye, R., Zhang, W., Hu, C., Zhou, B., Peterson, D.R., Au, D.W.T., Lam, P.K.S., Qian, P.Y.* Endocrine disruption throughout the hypothalamus-pituitary-gonadal-liver (HPGL) axis in marine medaka (Oryzias melastigma) chronically exposed to the antifouling and chemopreventive agent, 3,3'-diindolylmethane (DIM). Chemical Research in Toxicology 2016, 29, 1020–1028.

Marine Pollution Bulletin (IF: 3.241):

24. Chen, L., Lam, J.C.W, Zhang, X., Pan, K., Guo, C., Lam, P.K.S, Wang, W., Liu, H., Qian, P.Y.* Relationship between metal and polybrominated diphenyl ether (PBDE) body burden and health risks in the barnacle Balanus amphitrite. Marine Pollution Bulletin 2015, 100, 383–392.

Environmental Toxicology and Chemistry (IF: 3.179):

25. Chen, L., Huang, C., Hu, C., Yu, K., Yang, L., Zhou, B.* Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental Toxicology and Chemistry 2012, 31, 2338–2344.

26. Chen, L., Huang, Y., Huang, C., Hu, B., Hu, C., Zhou, B.* Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae. Environmental Toxicology and Chemistry 2013, 32, 1370–1375.

Progress in Organic Coatings (IF: 2.955):

27. Chen, L., Xia, C., Qian, P.Y.* Optimization of antifouling coatings incorporating butenolide, a potent antifouling agent via field and laboratory tests. Progress in Organic Coatings 2017, 109, 22–29. 

Marine Drugs (IF: 4.379):

28. Chen, L., Qian, P.Y.* Review on molecular mechanisms of antifouling compounds: An update since 2012. Marine Drugs 2017, 15, 264. 

Environmental Toxicology and Pharmacology (IF: 2.776):

29. Xu, T., Chen, L.,* Hu, C., Zhou, B. Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae. Environmental Toxicology and Pharmacology 2013, 35, 13–20.   

 

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