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姓 名:
 肖武汉
性 别:
 男
职 称:
 研究员
学 历:
 研究生
电 话:
 86-27-68780087
电子邮件:
 w-xiao@ihb.ac.cn

简历:

  博士, 研究员 1989年毕业于武汉大学, 获学士学位; 1997年在中国科学院水生生物研究所获博士学位。1994年至1998年在中国科学院水生生物研究所任助理研究员;199810月至200310月在美国西北大学(Northwestern University)做博士后研究, 任研究助理(Research Associate); 200310月至200512月在美国西北大学医学院任研究助理教授(Research Assistant Professor, Faculty member);从200512月开始,在中国科学院水生生物研究所任研究员; 20068月至10月在美国匹兹堡大学(University of Pittsburgh) 任研究顾问(Research Consultant)2006年入选中国科学院“百人计划”。 


研究方向:

1. 鱼类低氧耐受与低氧适应的遗传基础。 

2. 低氧信号转导的调控及其分子机制。 

3. 低氧信号转导与天然免疫的交互作用。 

4. 低氧信号转导与肿瘤转移的关系。 


专家类别:
百人

职务:

社会任职:

获奖及荣誉:
代表论著:

  2017 

  (1) Jianling Bi, Bo Hu, Jing Wang, Xing Liu, Jinsong Zheng, Ding Wang*, Wuhan Xiao*. Beluga whale pVHL enhances HIF-2a activity via inducing HIF-2a proteasomal degradation under hypoxia. Oncotarget, 2017, 8(26): 42272-42287.  

  (2) Dawei Zhang, Jing Wang, Chi Zhou, Wuhan Xiao*. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Mechanisms of Development. 2017, 143:42-52.  

    

  2016   

  (3) Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749. 

  (4) Xing Liu, Xiaolian Cai, Bo Hu, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705.  

  (5) Yu Chen, Chi Zhou, Wei Ji , Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nature Communications, 2016, 7: 11057. 

    

  2015 

(6) Xing Liu, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945.   

  (7) Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790.  

  (8) Zhichao Mei, Dawei Zhang, Bo Hu, Jing Wang, Xian Shen, Wuhan Xiao*. FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity. Journal of Biological Chemistry, 2015, 290(26): 16202-16214. 

  (9) Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098.  

    

  2014 

  (10) Bo Hu, Wei Zhang, Xi Feng, Wei Ji, Xunwei Xie, Wuhan Xiao*. Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis, Developmental Biology. 2014, 388: 81-93.  

  (11) Jing Wang, Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248.  

  (12) Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1a transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099.  

  (13) Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775.  

  (14) Wei Ji, Jing Wang, Wei Zhang, Xing Liu, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195.   

    

  2013 

  (15) Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development, 2013, 140: 1067-1078.   

    

  2011 

  (16) Xiaoyang Wan, Bo Hu, Jing-xia Liu, Xi Feng, Wuhan Xiao*. Zebrafish mll gene is essential for hematopoiesis. Journal of Biological Chemistry, 2011, 286: 33345-33357  

  (17) Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011, 30: 3397-3415.  

    

  2009 

  (18) Jiangang Zhou, Xi Feng, Bing Ban, Jing-xia Liu, Zhou Wang*, Wuhan Xiao*. The elongation factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation.Journal of Biological Chemistry, 2009, 284(28):19142-19152.  

  (19) Jing-xia Liu, Bo Hu, Yang Wang, Jianfang Gui, Wuhan Xiao*. Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. Journal of Biological Chemistry, 2009, 284(24):16679-16692.  

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